Invention Grant
- Patent Title: Compositions for targeted delivery of siRNA
- Patent Title (中): 用于靶向递送siRNA的组合物
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Application No.: US13615938Application Date: 2012-09-14
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Publication No.: US09011919B2Publication Date: 2015-04-21
- Inventor: David B. Rozema , David L. Lewis , Darren H. Wakefield , Torsten Hoffmann , Eric Kitas , Peter Mohr , Philipp Hadwiger , Wilma Thuer , Linda Valis
- Applicant: David B. Rozema , David L. Lewis , Darren H. Wakefield , Torsten Hoffmann , Eric Kitas , Peter Mohr , Philipp Hadwiger , Wilma Thuer , Linda Valis
- Applicant Address: US WI Madison
- Assignee: Arrowhead Madison Inc.
- Current Assignee: Arrowhead Madison Inc.
- Current Assignee Address: US WI Madison
- Agent Kirk Ekena
- Main IPC: A61K9/14
- IPC: A61K9/14 ; C07H21/02 ; C07K1/00 ; A61K47/32 ; A61K9/08 ; A61K48/00 ; C12N15/11 ; C12N15/87 ; A61K47/48
Abstract:
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
Public/Granted literature
- US20130245091A1 Compositions for Targeted Delivery of siRNA Public/Granted day:2013-09-19
Information query
