Invention Grant
- Patent Title: Sustained-release polymeric microparticles containing poorly water-soluble drug and method for preparing the same
- Patent Title (中): 含有水溶性差的药物的缓释性聚合物微粒及其制备方法
-
Application No.: US13995727Application Date: 2011-12-23
-
Publication No.: US09011921B2Publication Date: 2015-04-21
- Inventor: Sa Won Lee , Do Hoon Kim , Bong Oh Kim , Min Hyo Seo
- Applicant: Sa Won Lee , Do Hoon Kim , Bong Oh Kim , Min Hyo Seo
- Applicant Address: KR Seoul
- Assignee: Samyang Biopharmaceuticals Corporation
- Current Assignee: Samyang Biopharmaceuticals Corporation
- Current Assignee Address: KR Seoul
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: KR10-2010-0134633 20101224
- International Application: PCT/KR2011/010030 WO 20111223
- International Announcement: WO2012/087062 WO 20120628
- Main IPC: A61K9/50
- IPC: A61K9/50 ; A61K47/34 ; A01N25/28 ; A61K9/16 ; A61K31/175 ; A61K31/27 ; A61K31/436 ; A61K31/485 ; A61K31/519 ; A61K31/565 ; A61K31/57 ; A61K31/554
Abstract:
A sustained-release microparticle containing a poorly water-soluble drug is disclosed. The sustained-release microparticle containing a poorly water-soluble drug has a multivalent metal ion salt of polylactic acid having at least one terminal carboxyl group or a derivative thereof. The poorly water-soluble drug is entrapped in the multivalent metal ion salt of polylactic acid or a derivative thereof The polylactic acid has at least one terminal carboxyl group or a derivative thereof has an average molecular weight number from 500 to 5,000 daltons. A method for preparing a sustained-release polymeric microparticles containing a poorly water-soluble drug is provided.
Public/Granted literature
Information query
