Invention Grant
- Patent Title: Mutant AOX1 promoters
- Patent Title (中): 突变AOX1启动子
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Application No.: US11817005Application Date: 2006-02-23
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Publication No.: US09012175B2Publication Date: 2015-04-21
- Inventor: Franz Hartner , Anton Glieder
- Applicant: Franz Hartner , Anton Glieder
- Applicant Address: AT Graz AT Grambach
- Assignee: Technische Universitat Graz,VTU Holding GmbH
- Current Assignee: Technische Universitat Graz,VTU Holding GmbH
- Current Assignee Address: AT Graz AT Grambach
- Agency: Nevrivy Patent Law Group P.L.L.C.
- Priority: ATA304/2005 20050223
- International Application: PCT/AT2006/000079 WO 20060223
- International Announcement: WO2006/089329 WO 20060831
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/00 ; C12N15/81

Abstract:
A mutant Pichia pastoris alcohol oxidase 1 (AOX1) promoter of the wild type Pichia pastoris AOX1 promoter (SEQ ID No. 1) comprising at least one mutation selected from the group consisting of: a) a transcription factor binding site (TFBS), b) nucleotides 170 to 235 (−784 to −719), nucleotides 170 to 191 (−784 to −763), nucleotides 192 to 213 (−762 to −741), nucleotides 192 to 210 (−762 to −744), nucleotides 207 to 209 (−747 to −745), nucleotides 214 to 235 (−740 to −719), nucleotides 304 to 350 (−650 to −604), nucleotides 364 to 393 (−590 to −561), nucleotides 434 to 508 (−520 to −446), nucleotides 509 to 551 (−445 to −403), nucleotides 552 to 560 (−402 to −394), nucleotides 585 to 617 (−369 to −337), nucleotides 621 to 660 (−333 to −294), nucleotides 625 to 683 (−329 to −271), nucleotides 736 to 741 (−218 to −213), nucleotides 737 to 738 (−217 to −216), nucleotides 726 to 755 (−228 to −199), nucleotides 784 to 800 (−170 to −154) or nucleotides 823 to 861 (−131 to −93) of Seq ID No. 1, and combinations thereof.
Public/Granted literature
- US20080153126A1 Mutant Aox1 Promoters Public/Granted day:2008-06-26
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