Invention Grant
- Patent Title: Modified alcohol dehydrogenases for the production of fuels and chemicals
- Patent Title (中): 用于生产燃料和化学品的改性醇脱氢酶
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Application No.: US13025805Application Date: 2011-02-11
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Publication No.: US09012189B2Publication Date: 2015-04-21
- Inventor: Sabine Bastian , Frances Arnold , Peter Meinhold
- Applicant: Sabine Bastian , Frances Arnold , Peter Meinhold
- Applicant Address: US CO Englewood US CA Pasadena
- Assignee: Gevo, Inc.,The California Institute of Technology
- Current Assignee: Gevo, Inc.,The California Institute of Technology
- Current Assignee Address: US CO Englewood US CA Pasadena
- Agency: Cooley LLP
- Main IPC: C12P7/16
- IPC: C12P7/16 ; C12N15/81 ; C12N9/04
Abstract:
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
Public/Granted literature
- US20110201072A1 Modified alcohol dehydrogenases for the production of fuels and chemicals Public/Granted day:2011-08-18
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