Invention Grant
US09012405B2 Citrullinated fibrin-filaggrin chimeric polypeptide capable of detecting the antibodies generated in rheumatoid arthritis
有权
能够检测在类风湿性关节炎中产生的抗体的瓜氨酸纤维蛋白 - 丝聚蛋白嵌合多肽
- Patent Title: Citrullinated fibrin-filaggrin chimeric polypeptide capable of detecting the antibodies generated in rheumatoid arthritis
- Patent Title (中): 能够检测在类风湿性关节炎中产生的抗体的瓜氨酸纤维蛋白 - 丝聚蛋白嵌合多肽
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Application No.: US12598284Application Date: 2008-04-30
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Publication No.: US09012405B2Publication Date: 2015-04-21
- Inventor: Isabel Haro Villar , José M. Gomora Elena , Luisa M Perez Rodríguez , Raimon Sanmarti Sala
- Applicant: Isabel Haro Villar , José M. Gomora Elena , Luisa M Perez Rodríguez , Raimon Sanmarti Sala
- Applicant Address: ES ES
- Assignee: Consejo Superior de Investigaciones Cientificas,Fundacio Clinic per a la Recerca Biomedica
- Current Assignee: Consejo Superior de Investigaciones Cientificas,Fundacio Clinic per a la Recerca Biomedica
- Current Assignee Address: ES ES
- Agency: Merchant & Gould P.C.
- Priority: ES200701167 20070430
- International Application: PCT/ES2008/070087 WO 20080430
- International Announcement: WO2008/132264 WO 20081106
- Main IPC: G01N33/53
- IPC: G01N33/53 ; C07K7/64 ; G01N33/566 ; G01N33/564 ; C07K14/75 ; C07K14/78 ; G01N33/68 ; A61K38/00
Abstract:
The present invention concerns a chimeric polypeptide, capable of detecting the antibodies generated in rheumatoid arthritis, comprising at least two citrulinated peptide subunits: (i) one derived from the α or β chain of the fibrin and (ii) a second derived from the filaggrin. In addition, the invention comprises an antigenic composition, a method and a kit for the diagnosis of rheumatoid arthritis, from the detection of the autoantibodies generated during the course of said disease.
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