Invention Grant
US09012435B2 Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology
有权
糖皮质激素通过位置21上的芳族连接体连接到硝酸酯上，并且其在眼科学中的应用
- Patent Title: Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology
- Patent Title (中): 糖皮质激素通过位置21上的芳族连接体连接到硝酸酯上，并且其在眼科学中的应用
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Application No.: US13946794Application Date: 2013-07-19
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Publication No.: US09012435B2Publication Date: 2015-04-21
- Inventor: Francesca Benedini , Annalisa Bonfanti , Valerio Chiroli , Rebecca Steele , Ennio Ongini , Stefano Biondi
- Applicant: Nicox S.A.
- Applicant Address: FR Valbonne
- Assignee: Nicox S.A.
- Current Assignee: Nicox S.A.
- Current Assignee Address: FR Valbonne
- Agency: Arent Fox LLP
- Main IPC: A61K31/58
- IPC: A61K31/58 ; C07J71/00 ; C07J41/00
Abstract:
The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.
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