Invention Grant
- Patent Title: Pharmaceutical compositions containing an indoyl isoquinoline containing compound and uses thereof
- Patent Title (中): 含有含吲哚基异喹啉的化合物的药物组合物及其用途
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Application No.: US12296720Application Date: 2007-04-10
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Publication No.: US09012455B2Publication Date: 2015-04-21
- Inventor: Wen-Hwa Lee , Phang-Lang Chen , Longen Zhou , Jiewen Zhu
- Applicant: Wen-Hwa Lee , Phang-Lang Chen , Longen Zhou , Jiewen Zhu
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Fish & Tsang, LLP
- International Application: PCT/US2007/008969 WO 20070410
- International Announcement: WO2007/120726 WO 20071025
- Main IPC: A61K31/4725
- IPC: A61K31/4725 ; A61K31/506 ; A61K31/4745
Abstract:
Chronic myelogenous leukemia (CML), and in particular imatinib resistant CML is treated using compositions and methods in which a Rad51-inhibitor and a kinase inhibitor are administered. Most preferably, the Rad51 inhibitor comprises an indolyl isoquinoline structure and the kinase inhibitor is a BCR-ABL inhibitor.
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