Invention Grant
US09012494B2 Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
有权
吡咯烷-2-酮和哌啶-2-酮衍生物作为11-β羟基类固醇脱氢酶抑制剂
- Patent Title: Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
- Patent Title (中): 吡咯烷-2-酮和哌啶-2-酮衍生物作为11-β羟基类固醇脱氢酶抑制剂
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Application No.: US11632675Application Date: 2005-04-29
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Publication No.: US09012494B2Publication Date: 2015-04-21
- Inventor: Libuse Jaroskova , Joannes Theodorus Maria Linders , Christophe Francis Robert Nestor Buyck , Louis Jozef Elisabeth Van Der Veken , Vladimir Dimtchev Dimitrov , Theo Teofanov Nikiforov
- Applicant: Libuse Jaroskova , Joannes Theodorus Maria Linders , Christophe Francis Robert Nestor Buyck , Louis Jozef Elisabeth Van Der Veken , Vladimir Dimtchev Dimitrov , Theo Teofanov Nikiforov
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica N.V.
- Current Assignee: Janssen Pharmaceutica N.V.
- Current Assignee Address: BE Beerse
- Priority: EP04101991 20040507
- International Application: PCT/EP2005/051968 WO 20050429
- International Announcement: WO2005/108360 WO 20051117
- Main IPC: A61K31/4015
- IPC: A61K31/4015 ; C07D207/12 ; C07D207/267 ; C07D207/26 ; C07D211/76 ; C07D405/06

Abstract:
The N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 1 or 2; L represents a C1-3alkyl linker optionally substituted with one or two substituents selected from C1-4alkyl, C1-3alkyloxy-C1-4alkyl-, hydroxy-C1-4alkyl, hydroxy, C1-3alkyloxy- or phenyl-C1-4alkyl; M represents a direct bond or a C1-3alkyl linker optionally substituted with one or two substituents selected from hydroxy, C1-4alkyl or C1-4alkyloxy; R1 and R2 each independently represent hydrogen, halo, cyano, hydroxy, C1-4alkyl optionally substituted with halo, C1-4alkyloxy- optionally substituted with one or where possible two or three substituents selected from hydroxy, Ar1 and halo; or R1 and R2 taken together with the phenyl ring to which they are attached form naphtyl or 1,3-benzodioxolyl, wherein said naphtyl or 1,3-benzodioxolyl are optionally substituted with halo; R3 represents hydrogen, halo, C1-4alkyl, C1-4alkyloxy-, cyano or hydroxy; R4 represents hydrogen, halo, C1-4alkyl, C1-4alkyloxy-, cyano or hydroxy; R5 represents hydrogen, C1-4alkyl or Ar2-C1-4alky-; R6 represents hydrogen, halo, C1-4alkyl or C1-4alkyoxy-; Ar1 and Ar2 each independently represent phenyl or naphtyl wherein said phenyl and naphtyl are optionally substituted with C1-4alkyl, C1-4alkyloxy-, or phenyl-C1-4alkyl; for use as a medicine.
Public/Granted literature
- US20080139625A1 Pyrrolidin-2-One and Piperidin-2-One Derivatives as 11-Beta Hydroxysteroid Dehydrogenase Inhibitors Public/Granted day:2008-06-12
Information query
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