Invention Grant
US09012624B2 Compositions and methods for inhibiting expression of a gene from the JC virus
有权
用于抑制基因从JC病毒表达的组合物和方法
- Patent Title: Compositions and methods for inhibiting expression of a gene from the JC virus
- Patent Title (中): 用于抑制基因从JC病毒表达的组合物和方法
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Application No.: US13779116Application Date: 2013-02-27
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Publication No.: US09012624B2Publication Date: 2015-04-21
- Inventor: Pamela Tan , Dinah Sah , Birgit Bramlage
- Applicant: Alnylam Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Fenwick & West LLP
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C12N15/11 ; A61K48/00
Abstract:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.
Public/Granted literature
- US20130158102A1 Compositions and Methods for Inhibiting Expression of a Gene from the JC Virus Public/Granted day:2013-06-20
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