Invention Grant
US09012645B2 Process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide and synthetic intermediates thereof
有权
制备6-（7 - （（1-氨基环丙基）甲氧基）-6-甲氧基喹啉-4-基氧基）-N-甲基-1-萘甲酰胺的方法及其合成中间体
- Patent Title: Process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide and synthetic intermediates thereof
- Patent Title (中): 制备6-（7 - （（1-氨基环丙基）甲氧基）-6-甲氧基喹啉-4-基氧基）-N-甲基-1-萘甲酰胺的方法及其合成中间体
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Application No.: US14138302Application Date: 2013-12-23
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Publication No.: US09012645B2Publication Date: 2015-04-21
- Inventor: Silvano Spinelli , Valeria Livi
- Applicant: EOS Ethical Oncology Science S.p.A.
- Applicant Address: IT Milan
- Assignee: Clovis Oncology Italy S.R.L.
- Current Assignee: Clovis Oncology Italy S.R.L.
- Current Assignee Address: IT Milan
- Agency: Swanson & Bratschun, L.L.C.
- Priority: ITMI2009A0397 20090316
- Main IPC: C07D215/38
- IPC: C07D215/38 ; C07D215/22 ; C07C217/44 ; C07C271/24 ; C07C269/04
Abstract:
A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.
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