A method for operating a LED lighting system has three or more LED emitters of different colors. The method allows finding the optimal drive setting for each LED emitter of the system, taking into account a specific target color. The method involves providing calibration data for each LED emitter at a plurality of values of drive setting and junction temperature, and executing a drive recursion loop calculating the drive setting of each emitter based on an input value for the temperature of each emitter and in view of the target output color and of the calibration data. Advantageously, this can be accomplished without measuring the color emitted by the LED lighting system, that is, no color feedback is required. A LED lighting system implementing the method is also disclosed.