Certain aspects of an apparatus and method for method and apparatus for automatic HER2 scoring of tissue samples may include for determining a cancer diagnosis score comprising identifying one or more nuclei in a slide image of a tissue sample, determine one or more membrane strengths in the slide image surrounding each of the one or more nuclei, classifying one or more cells, each corresponding to the one or more nuclei, in a class among a plurality of classes according to the one or more membrane strengths and determining a cancer diagnosis score based on a percentage of cells classified in each of the plurality of classes.