Embodiments of the present disclosure provide a novel multi-mode platform architecture with means for reducing the interference due to both out-of-band (OOB) emissions and inter-modulation distortion (IMD) products caused by a first radio access technology (RAT) transmitter on a co-located second RAT receiver. The multi-mode platform architecture may be used in a variety of wireless devices and with a variety of co-located RATs, including, without limitation, WiFi, LTE, WiMAX, WCDMA, Bluetooth, and Zigbee, for example.