A protective clamp frame having a power and unclamp duplex button for mobile communication devices is disclosed, comprising a main frame, an auxiliary frame and a connection control element, wherein the main frame and the auxiliary frame are both configured in a closed frame structure, and the main frame is formed with a central recessed accommodating part for receiving a mobile communication device, further overlapped with the auxiliary frame, such that the lateral sides of the mobile communication device can be peripherally wrapped; in addition, the connection control element can release the connection between the main frame and the auxiliary frame and operate to engage in touch with the power switch on the mobile communication device in order to provide a duplex structure having power activation and unclamp frame features.