An operation system for cooperatively responding to a target moving in the air by an aircraft and a flying object launched from a launch facility. A control facility (16) receives target information including information indicating a position of a target aircraft (18) moving in the air, and SAM information including information indicating a position of a SAM (20) launched from a launch facility (12) toward the target aircraft (18). The control facility (16) then calculates a course of the SAM (20) heading for the target aircraft (18) based on the received target information and SAM information as a no-fly zone of an aircraft (14) that responds to the target aircraft (18).