Invention Grant
US09018175B2 3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives
有权
3,4,4a，10b-四氢-1H-噻喃并[4,3-c]异喹啉衍生物
![3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives](/docs/US/2015-04-28/US09018175B2/abs.jpg.600x600.jpg)
- Patent Title: 3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives
- Patent Title (中): 3,4,4a，10b-四氢-1H-噻喃并[4,3-c]异喹啉衍生物
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Application No.: US13515214Application Date: 2010-12-15
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Publication No.: US09018175B2Publication Date: 2015-04-28
- Inventor: Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
- Applicant: Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
- Applicant Address: DE Constance
- Assignee: Takeda GmbH
- Current Assignee: Takeda GmbH
- Current Assignee Address: DE Constance
- Agency: Nath, Goldberg & Meyer
- Agent Joshua B. Goldberg
- Priority: EP09179982 20091218
- International Application: PCT/EP2010/069704 WO 20101215
- International Announcement: WO2011/073231 WO 20110623
- Main IPC: A61K31/56
- IPC: A61K31/56 ; A61K31/519 ; A61K31/5585 ; C07D495/04 ; C07D519/00
![3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives](/abs-image/US/2015/04/28/US09018175B2/abs.jpg.150x150.jpg)
Abstract:
The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
Public/Granted literature
- US20120289474A1 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4,3-c] ISOQUINOLINE DERIVATIVES Public/Granted day:2012-11-15
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