A method is provided for detecting a corresponding region of interest in digital medical images, the method including receiving a plurality of digital images including a primary image, at least one of the images being a projective image, identifying anatomical landmarks and structures within each of the images and correlating the images based on the identified anatomical landmarks and structures identifying a location of interest in the primary image, and automatically identifying a region of interest in the rest of the images, the region of interest corresponding to the identified location of interest in the primary image.