An off-line graphical user interface (GUI) system and method provide for input control of a three-dimensional coordinate measuring machine (CMM) using the CMM's probe. A GUI image presents a plurality of control operation icons associated with the CMM. A controller uses the CMM to locate the GUI image in a coordinate system of the CMM. The controller defines coordinates of the control operation icons and references the coordinates to the coordinate system of the CMM. The controller also defines a function activation zone associated with each of the control operation icons. Each function activation zone defines criteria relating movement of the CMM's probe therein to the operational function of the CMM associated with one of the control operation icons corresponding thereto. Satisfaction of the criteria causes the operational function of the CMM to be carried out by the CMM.