An access assembly includes a housing defining a longitudinal axis and having a longitudinal opening therethrough, a cannula extending distally from the housing and in fluid communication with the longitudinal opening and a seal member mounted within the longitudinal opening of the housing. The seal member is configured to receive an instrument therethrough in substantial sealed relation therewith. The housing is adapted to move in at least a radial direction with respect to the longitudinal axis whereby the seal member maintains the substantial sealed relation relative to the instrument as the instrument in manipulated. The housing may be flexible and capable of deflection relative to the longitudinal axis. The housing may comprise an elastomeric material in whole or in part. The seal member may be integrally formed with the housing. The housing may include at least one flexible ring portion and possibly a plurality of ring portions.