Invention Grant
- Patent Title: Synthesis of 18F-labeled tracers in hydrous organic solvents
- Patent Title (中): 在含水有机溶剂中合成18F标记的示踪剂
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Application No.: US13634708Application Date: 2011-04-08
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Publication No.: US09023316B2Publication Date: 2015-05-05
- Inventor: Umesh Gangadharmath , Joseph Walsh , Hartmuth Kolb
- Applicant: Umesh Gangadharmath , Joseph Walsh , Hartmuth Kolb
- Applicant Address: US PA Malvern
- Assignee: Siemens Medical Solutions USA, Inc.
- Current Assignee: Siemens Medical Solutions USA, Inc.
- Current Assignee Address: US PA Malvern
- Agent Peter Kendall
- International Application: PCT/US2011/031681 WO 20110408
- International Announcement: WO2011/127345 WO 20111013
- Main IPC: C07B59/00
- IPC: C07B59/00 ; B01D15/36 ; A61K51/04

Abstract:
A method for synthesizing an 18F-labeled probe. The method includes a step of eluting an amount of 18F with a first solvent which includes a predetermined amount of water and at least one organic solvent. In this step, the 18F elutes as an 18F solution. The method also includes a step of using the 18F solution to perform 18F-labeling in the presence of at least one labeling reagent and at least one phase transfer catalyst so as to generate the 18F-labeled probe. In the method, there is no step of drying the 18F starting from a time when the eluting step is performed and ending at a time when the 18F-labeling step is performed.
Public/Granted literature
- US20130005956A1 Synthesis of 18F-labeled Tracers in Hydrous Organic Solvents Public/Granted day:2013-01-03
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