Invention Grant
- Patent Title: Triazole macrocycle systems
- Patent Title (中): 三唑大环系统
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Application No.: US13370057Application Date: 2012-02-09
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Publication No.: US09023988B2Publication Date: 2015-05-05
- Inventor: Huw M. Nash
- Applicant: Huw M. Nash
- Applicant Address: US MA Cambridge
- Assignee: Aileron Therapeutics, Inc.
- Current Assignee: Aileron Therapeutics, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Wilson Sonsini Goodrich & Rosati
- Main IPC: C07K2/00
- IPC: C07K2/00 ; C07K4/00 ; C07K1/00 ; C07K1/107 ; C07K7/08 ; C07K7/56 ; C07K14/47 ; C07C271/22
Abstract:
The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production. Macrocycles of the invention include triazole moieties that crosslink amino acid side chains. The cross links can stabilize a secondary structure of a peptidomimetic macrocycle, such as an α-helix.
Public/Granted literature
- US20120190818A1 TRIAZOLE MACROCYCLE SYSTEMS Public/Granted day:2012-07-26
Information query
