Invention Grant
- Patent Title: Octahydro-cyclopentapyrrolyl antagonists of CCR2
- Patent Title (中): CCR2的八氢环戊吡咯基拮抗剂
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Application No.: US13943099Application Date: 2013-07-16
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Publication No.: US09024017B2Publication Date: 2015-05-05
- Inventor: Chaozhong Cai , David F. McComsey , Zhihua Sui , Fu-An Kang
- Applicant: Janssen Pharmaceutica NV
- Applicant Address: BE Belgium
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Belgium
- Agent Mary A. Appollina
- Main IPC: C07D471/02
- IPC: C07D471/02 ; A61K31/5377 ; C07D471/04 ; C07D405/12 ; C07D405/14

Abstract:
The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, Z1 and Z2 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
Public/Granted literature
- US20140024646A1 OCTAHYDRO-CYCLOPENTAPYRROLYL ANTAGONISTS OF CCR2 Public/Granted day:2014-01-23
Information query