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US09024017B2 Octahydro-cyclopentapyrrolyl antagonists of CCR2 有权
CCR2的八氢环戊吡咯基拮抗剂

Octahydro-cyclopentapyrrolyl antagonists of CCR2
Abstract:
The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, Z1 and Z2 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
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