Invention Grant
- Patent Title: Materials and methods useful to induce cell death via methuosis
- Patent Title (中): 用于通过甲基化诱导细胞死亡的材料和方法
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Application No.: US14001313Application Date: 2012-02-24
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Publication No.: US09028796B2Publication Date: 2015-05-12
- Inventor: William A. Maltese , Paul W. Erhardt , Michael W. Robinson , Jean H. Overmeyer
- Applicant: William A. Maltese , Paul W. Erhardt , Michael W. Robinson , Jean H. Overmeyer
- Applicant Address: US OH Toledo
- Assignee: The University of Toledo
- Current Assignee: The University of Toledo
- Current Assignee Address: US OH Toledo
- Agency: MacMillan, Sobanski & Todd, LLC
- International Application: PCT/US2012/026609 WO 20120224
- International Announcement: WO2012/145069 WO 20121026
- Main IPC: C07D401/06
- IPC: C07D401/06 ; A61K45/06 ; A61K31/4439 ; A61K31/404 ; C07D403/06 ; C07D209/08 ; C07D209/12 ; C40B40/04
Abstract:
The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
Public/Granted literature
- US20140322128A1 Materials and Methods Useful to Induce Cell Death via Methuosis Public/Granted day:2014-10-30
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