Invention Grant
- Patent Title: Methods for promoting HSC self-renewal
- Patent Title (中): 促进HSC自我更新的方法
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Application No.: US13431563Application Date: 2012-03-27
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Publication No.: US09028811B2Publication Date: 2015-05-12
- Inventor: Leonard I. Zon , Trista E. North , Wolfram Goessling
- Applicant: Leonard I. Zon , Trista E. North , Wolfram Goessling
- Applicant Address: US MA Boston US MA Boston
- Assignee: Children's Medical Center Corporation,The General Hospital Corporation
- Current Assignee: Children's Medical Center Corporation,The General Hospital Corporation
- Current Assignee Address: US MA Boston US MA Boston
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Tari W. Mills
- Main IPC: A01N63/00
- IPC: A01N63/00 ; C12N5/00 ; A61K35/14 ; C12N5/0789 ; A61K35/28 ; A61K45/06
Abstract:
The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
Public/Granted literature
- US20120189594A1 METHODS FOR PROMOTING HSC SELF-RENEWAL Public/Granted day:2012-07-26
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