Invention Grant
US09028813B2 Methods of degrading or inhibiting botulinum neurotoxin using designer ubiquitin ligases
有权
使用设计师泛素连接酶降解或抑制肉毒杆菌神经毒素的方法
- Patent Title: Methods of degrading or inhibiting botulinum neurotoxin using designer ubiquitin ligases
- Patent Title (中): 使用设计师泛素连接酶降解或抑制肉毒杆菌神经毒素的方法
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Application No.: US13726915Application Date: 2012-12-26
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Publication No.: US09028813B2Publication Date: 2015-05-12
- Inventor: George A. Oyler , Yien Che Tsai
- Applicant: Synaptic Research, LLC
- Applicant Address: US MD Baltimore
- Assignee: Synaptic Research, LLC
- Current Assignee: Synaptic Research, LLC
- Current Assignee Address: US MD Baltimore
- Agency: AGG Intellectual Property Law
- Agent Antoinette G. Giugliano
- Main IPC: A61K38/43
- IPC: A61K38/43 ; C12N9/00 ; C12N1/20 ; C12N15/00 ; C07H21/04 ; A61K38/48
Abstract:
The present invention relates to a designer or recombinant ubiquitin ligase molecule that includes a toxin binding domain that is specific for a toxin active fragment, wherein the toxin active fragment is an enzymatically active fragment of one or more toxins or toxin serotypes; and an E3-ligase domain that comprises an E3-ligase or polypeptide that facilitates E2-mediated ubiquitination of the toxin active fragment. In an embodiment, the composition further includes a delivery system that allow the designer ubiquitin ligase to enter the cell. The present invention further includes methods for treating an individual intoxicated with a toxin by administering the designer ubiquitin ligase of the present invention.
Public/Granted literature
- US20130251699A1 DESIGNER UBIQUITIN LIGASES FOR REGULATION OF INTRACELLULAR PATHOGENIC PROTEINS Public/Granted day:2013-09-26
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