Invention Grant
- Patent Title: Recombinant virus comprising an intact tumor-therapeutic antibody with human constant regions and the use thereof
- Patent Title (中): 包含具有人恒定区的完整肿瘤治疗性抗体的重组病毒及其用途
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Application No.: US10554902Application Date: 2004-04-29
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Publication No.: US09029133B2Publication Date: 2015-05-12
- Inventor: Qijun Qian , Qi Zhang , Qin Yang , Mengchao Wu
- Applicant: Qijun Qian , Qi Zhang , Qin Yang , Mengchao Wu
- Agency: Ladas & Parry LLP
- Priority: CN03116733 20030430
- International Application: PCT/CN2004/000430 WO 20040429
- International Announcement: WO2004/101777 WO 20041125
- Main IPC: C12N15/861
- IPC: C12N15/861 ; A61K39/235 ; C07K16/28 ; C07K16/32 ; C12N15/86 ; A61K39/00
Abstract:
The present invention provides a recombinant virus containing a nucleotide sequence encoding a tumor-therapeutic full-length antibody with human constant regions, and uses thereof. After a nucleotide sequence of a gene encoding a tumor-therapeutic full-length antibody with human constant regions of the light chain and the heavy chain is inserted into the genome of a recombinant virus, the tumor-therapeutic full-length antibody with human constant regions can be efficiently expressed in tumor cells, thereby inhibit the growth and metastasis of tumors.
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