Invention Grant
US09029322B2 Compounds for enhancing p21 expression and methods of use thereof
有权
用于增强p21表达的化合物及其使用方法
- Patent Title: Compounds for enhancing p21 expression and methods of use thereof
- Patent Title (中): 用于增强p21表达的化合物及其使用方法
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Application No.: US12663091Application Date: 2008-06-05
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Publication No.: US09029322B2Publication Date: 2015-05-12
- Inventor: Rajiv R. Ratan , Brett C. Langley , Brian S. Ko
- Applicant: Rajiv R. Ratan , Brett C. Langley , Brian S. Ko
- Applicant Address: US NY Ithaca
- Assignee: Cornell University
- Current Assignee: Cornell University
- Current Assignee Address: US NY Ithaca
- Agency: Hoffmann & Baron, LLP
- International Application: PCT/US2008/007168 WO 20080605
- International Announcement: WO2008/150550 WO 20081211
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/28 ; A61P3/10 ; A61P7/12 ; C12Q1/68 ; A01N43/42 ; A61K31/44 ; A01N43/40 ; A01N43/16 ; A61K31/35 ; A01N37/12 ; A01N37/44 ; A61K31/195 ; A01N47/28 ; A61K31/17 ; A01N57/00 ; A61K31/675 ; C07K14/47 ; G01N33/50
Abstract:
The present invention relates to a method for identifying a drug candidate for enhancing expression of p21cip1/waf1 in a human patient suffering from a medical condition that can be treated by enhancing expression of p21Cφ1/waf1. The method includes (a) providing a cell line comprising a nucleic acid sequence that comprises a p21cip1/waf1 promoter operationally ligated to a reporter domain; (b) exposing the cell line to a compound; and (c) identifying a compound that induces expression of the reporter domain. The compound that induces expression of the reporter domain is a drug candidate for treating a medical condition that can be treated by enhancing expression of p21cip1/waf1.
Public/Granted literature
- US20100167993A1 Compounds for Enhancing p21 Expression and Methods of Use Thereof Public/Granted day:2010-07-01
Information query
IPC分类:
