Invention Grant
US09029328B2 Methods for cardioprotection and cardioregeneration with dimers of EGF family ligands
有权
心脏保护和心脏再生与EGF家族配体二聚体的方法
- Patent Title: Methods for cardioprotection and cardioregeneration with dimers of EGF family ligands
- Patent Title (中): 心脏保护和心脏再生与EGF家族配体二聚体的方法
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Application No.: US13636578Application Date: 2011-03-24
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Publication No.: US09029328B2Publication Date: 2015-05-12
- Inventor: Steven M. Jay , Linda G. Griffith , Richard T. Lee
- Applicant: Steven M. Jay , Linda G. Griffith , Richard T. Lee
- Applicant Address: US MA Boston US MA Cambridge
- Assignee: The Brigham and Women's Hospital, Inc.,Massachusetts Institute of Technology
- Current Assignee: The Brigham and Women's Hospital, Inc.,Massachusetts Institute of Technology
- Current Assignee Address: US MA Boston US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2011/029799 WO 20110324
- International Announcement: WO2011/119836 WO 20110929
- Main IPC: A61P9/04
- IPC: A61P9/04 ; A61K38/22 ; A61K38/16 ; A61K38/18 ; A61K38/17 ; C07K14/475 ; C07K14/485 ; C07K19/00
Abstract:
The invention provides methods and compositions for reducing, preventing or reversing cardio toxicity side effects associated with certain therapeutic agents. The invention also provides methods and compositions for treating heart dysfunction including heart failure, and for reversing the effects of myocardial infarction. The various aspects of the invention involve the use of ligand dimers, such as neuregulin dimers, that selectively induce the dimerization of certain EGF receptors in cardiac tissue.
Public/Granted literature
- US20130196911A1 METHODS AND COMPOSITIONS FOR CARDIOPROTECTION AND CARDIOREGENERATION Public/Granted day:2013-08-01
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