Invention Grant
US09029330B2 Methods of treating cancer using interleukin-12p40 variants having improved stability
有权
使用具有改善的稳定性的白细胞介素-12p40变体治疗癌症的方法
- Patent Title: Methods of treating cancer using interleukin-12p40 variants having improved stability
- Patent Title (中): 使用具有改善的稳定性的白细胞介素-12p40变体治疗癌症的方法
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Application No.: US13478897Application Date: 2012-05-23
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Publication No.: US09029330B2Publication Date: 2015-05-12
- Inventor: Gordon D. Webster , Suzanne P. McKenzie , Kin-Ming Lo , Pascal André Stein
- Applicant: Gordon D. Webster , Suzanne P. McKenzie , Kin-Ming Lo , Pascal André Stein
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Goodwin Procter LLP
- Main IPC: A61P35/00
- IPC: A61P35/00 ; H04N21/61 ; H04N21/462 ; H04N21/8549 ; C07H21/04 ; C12N1/21 ; C12N5/16 ; C12P21/04 ; C12N15/09 ; C07K14/54 ; C07K19/00 ; A61K38/00
Abstract:
Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.
Public/Granted literature
- US20130034518A1 Interleukin-12 P40 Variants with Improved Stability Public/Granted day:2013-02-07
Information query
IPC分类:
| A | 人类生活必需 |
| A61 | 医学或兽医学；卫生学 |
| A61P | 化合物或药物制剂的特定治疗活性 |
| A61P35/00 | 抗肿瘤药 |
