Invention Grant
US09029366B2 Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mGluR5 receptors
有权
取代的双环烷氧基吡唑类似物作为mGluR5受体的变构调节剂
- Patent Title: Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mGluR5 receptors
- Patent Title (中): 取代的双环烷氧基吡唑类似物作为mGluR5受体的变构调节剂
-
Application No.: US13922223Application Date: 2013-06-19
-
Publication No.: US09029366B2Publication Date: 2015-05-12
- Inventor: P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , José Manuel Bartolomé-Nebreda , Susana Conde-Ceide , Gregor James Macdonald , Han Min Tong , Miguel Angel Pena-Piñón , Manuel Jesús Alcázar-Vaca , José Ignacio Andrés-Gil
- Applicant: Vanderbilt University
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Ballard Spahr LLP
- Main IPC: A61K31/535
- IPC: A61K31/535 ; A01N43/62 ; A61K31/55 ; C07D487/04
Abstract:
In one aspect, the invention relates to substituted bicyclic alkoxy pyrazole analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Public/Granted literature
- US20130345203A1 SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS Public/Granted day:2013-12-26
Information query
