Invention Grant
- Patent Title: Bisaryl (thio)morpholine derivatives as S1P modulators
- Patent Title (中): 二芳基（硫代）吗啉衍生物作为S1P调节剂
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Application No.: US13808900Application Date: 2011-07-08
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Publication No.: US09029371B2Publication Date: 2015-05-12
- Inventor: Wouter I. Iwema Bakker , Raymond Bronger
- Applicant: Wouter I. Iwema Bakker , Raymond Bronger
- Applicant Address: NL Hoofddorp
- Assignee: Abbvie B.V.
- Current Assignee: Abbvie B.V.
- Current Assignee Address: NL Hoofddorp
- Agency: Michael Best & Friedrich LLP
- Agent Lisa V. Mueller
- Priority: EP10169108 20100709; EP11158269 20110315
- International Application: PCT/EP2011/061590 WO 20110708
- International Announcement: WO2012/004375 WO 20120112
- Main IPC: C07D295/15
- IPC: C07D295/15 ; C07D265/30 ; C07D413/10 ; A61K31/5377 ; A61K31/5375
Abstract:
The present invention relates to bisaryl (thio)morpholine derivatives of the formula (I) or a pharmaceutically acceptable salt, a solvate or hydrate thereof, with the proviso that the derivative of formula (I) is not 2-[4-(4-chlorophenoxy)-2-chlorophenyl]-4 -morpholineethanol. The compounds of the invention have affinity to S1 Preceptors and may be used in the treatment, alleviation or prevention of S1 Preceptor mediated diseases and conditions.
Public/Granted literature
- US20130203745A1 BISARYL (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS Public/Granted day:2013-08-08
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