Invention Grant
US09029382B2 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
有权
3,5-二氨基-6-氯-N-（N-（4-苯基丁基）氨基甲脒基）吡嗪-2-甲酰胺化合物
- Patent Title: 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
- Patent Title (中): 3,5-二氨基-6-氯-N-（N-（4-苯基丁基）氨基甲脒基）吡嗪-2-甲酰胺化合物
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Application No.: US14106098Application Date: 2013-12-13
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Publication No.: US09029382B2Publication Date: 2015-05-12
- Inventor: Michael R. Johnson
- Applicant: Parion Sciences, Inc.
- Applicant Address: US NC Durham
- Assignee: Parion Sciences, Inc.
- Current Assignee: Parion Sciences, Inc.
- Current Assignee Address: US NC Durham
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Main IPC: C07D241/28
- IPC: C07D241/28 ; A61K31/4965 ; A61K45/06 ; A61K9/00
Abstract:
The present invention relates compounds of the formula: or pharmaceutically acceptable salts thereof, useful as sodium channel blockers, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including cystic fibrosis, chronic obstructive pulmonary disease, asthma, bronchiectasis, acute and chronic bronchitis, emphysema, and pneumonia.
Public/Granted literature
- US20140170244A1 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS Public/Granted day:2014-06-19
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