Invention Grant
- Patent Title: Method for native ligation of polypeptides
- Patent Title (中): 天然连接多肽的方法
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Application No.: US13504054Application Date: 2010-10-28
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Publication No.: US09029503B2Publication Date: 2015-05-12
- Inventor: Oleg Melnyk , Reda Mhidia , Julien Dheur , Nathalie Ollivier
- Applicant: Oleg Melnyk , Reda Mhidia , Julien Dheur , Nathalie Ollivier
- Applicant Address: FR Paris FR Lille Cedex
- Assignee: Centre National de la Recherche Scientifique,Institut Pasteur de Lille
- Current Assignee: Centre National de la Recherche Scientifique,Institut Pasteur de Lille
- Current Assignee Address: FR Paris FR Lille Cedex
- Agency: Alston & Bird LLP
- Priority: FR0957639 20091029
- International Application: PCT/IB2010/054897 WO 20101028
- International Announcement: WO2011/051906 WO 20110505
- Main IPC: C07K1/10
- IPC: C07K1/10 ; C07K2/00 ; C07K1/02
Abstract:
The invention mainly relates to a method for manufacturing a polypeptide of formula: X1—X″—X2 (III) X1 and X2 each representing a peptide fragment, and X″ representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula: X1—N(CH2CH2SH)2 (I) and a polypeptide of formula: H—X″—X2. (II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.
Public/Granted literature
- US20120220721A1 Method for Native Ligation of Polypeptides Public/Granted day:2012-08-30
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