Invention Grant
US09029563B2 Substituted 1-benzylindolin-2-one analogs as positive allosteric modulators of muscarinic acetylcholine M1 receptors
有权
取代的1-苄基二氢吲哚-2-酮类似物作为毒蕈碱性乙酰胆碱M1受体的正变构调节剂
- Patent Title: Substituted 1-benzylindolin-2-one analogs as positive allosteric modulators of muscarinic acetylcholine M1 receptors
- Patent Title (中): 取代的1-苄基二氢吲哚-2-酮类似物作为毒蕈碱性乙酰胆碱M1受体的正变构调节剂
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Application No.: US13735017Application Date: 2013-01-06
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Publication No.: US09029563B2Publication Date: 2015-05-12
- Inventor: Craig W. Lindsley , P. Jeffrey Conn , Michael R. Wood , Bruce J. Melancon , Michael S. Poslusney
- Applicant: Vanderbilt University
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Ballard Spahr LLP
- Main IPC: C07D403/10
- IPC: C07D403/10 ; A61K31/4155 ; A61K31/416 ; A61K31/4439 ; A61K45/06 ; C07D401/14
Abstract:
In one aspect, the invention relates to substituted 1-benzylindolin-2-one analog compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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