A cable protection and guide device is provided, which prevents abrasion of the cable skin of a cable or the like and holds the position of a multi joint link with high precision. The cable protection and guide device is characterized in that the multi-joint link includes a link member and a holding member attached to the link member for holding the cable. The holding member includes a cylindrical base portion and a holding portion formed integrally with the cylindrical base portion, wherein the cylindrical base portion is engaged with a circular through hole of the link member, and the holding portion extends outward from the cylindrical base portion in a multi joint link width direction and is bifurcated for holding the cable from two sides, i.e. multi-joint link flexional inner side and multi-joint link flexional outer side. The holding member is rotatable with respect to the link member.