Described are techniques for managing the interference produced by D2D (device-to-device) transmissions that may be used in conjunction with transmit power control but operate independently. In one technique, interference between D2D transmissions and cellular uplink transmissions using common resources as received at a base station is managed by opportunistic interference alignment and clustering of D2D devices. In another technique, interference between different D2D devices using the same resources is mitigated by base-station aided space-time interference alignment.