Disclosed are an oil pump control system and method, the oil pump control method including setting an initial target oil pressure of the oil pump based on a rotation speed of an engine or an oil temperature, determining a pressure compensation value by considering the target torque or target fuel quantity of the engine based on the initial target oil pressure, determining a final target oil pressure by adding the pressure compensation value to the initial target oil pressure, and feedback-controlling the oil pump so that current oil pressure measured in real time follows the final target oil pressure.