Invention Grant
- Patent Title: Apparatus for synthesizing oligonucleotides and methods of use
- Patent Title (中): 用于合成寡核苷酸的装置和使用方法
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Application No.: US13375697Application Date: 2010-05-28
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Publication No.: US09034272B2Publication Date: 2015-05-19
- Inventor: Isaiah E. Cedillo , Max N. Moore , Francis J. Ring
- Applicant: Isaiah E. Cedillo , Max N. Moore , Francis J. Ring
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Casimir Jones, S.C.
- International Application: PCT/US2010/036599 WO 20100528
- International Announcement: WO2010/141361 WO 20101209
- Main IPC: B01J8/02
- IPC: B01J8/02 ; B01J19/00 ; C12M1/00
Abstract:
The present invention relates to apparatus and methods for synthesizing oligonucleotides wherein a reaction zone has a variable volume based on the position of a piston, and the piston is adjusted to control the amount of headspace above solid support in the reaction zone. Methods and apparatus that limit the size or existence of the headspace are described.
Public/Granted literature
- US20120107181A1 APPARATUS FOR SYNTHESIZING OLIGONUCLEOTIDES AND METHODS OF USE Public/Granted day:2012-05-03
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