中科微点-全球专利检索

  1. Login
  2. Sign Up
Invention Grant
US09034329B2 Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof 有权
制备抗体或抗体片段靶向免疫脂质体用于全身给药治疗剂或诊断剂及其用途

Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
Abstract:
The present invention provides methods of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprising (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex. The present invention also provides cationic immunoliposome or polymer complexes produced by such methods and compositions comprising such complexes. The present invention also provides methods for treating various diseases and disorders, including cancers, by administering the complexes and compositions of the invention to a patient.
Abstract(Chinese):

本发明提供制备抗体或抗体片段靶向阳离子免疫脂质体或聚合物复合物的方法，其包括（a）制备抗体或抗体片段; （b）将所述抗体或抗体片段与阳离子脂质体混合以形成阳离子免疫脂质体或用阳离子聚合物形成聚合物; 和（c）将所述阳离子免疫脂质体或所述多聚体与治疗剂或诊断剂混合以形成所述抗体或抗体片段靶向阳离子免疫脂质体或聚合物复合物。 本发明还提供了由包含这种复合物的方法和组合物制备的阳离子免疫脂质体或聚合物复合物。 本发明还提供了通过将本发明的复合物和组合物给予患者来治疗各种疾病和病症（包括癌症）的方法。

Public/Granted literature
Information query
Espacenet
Patent Agency Ranking
0/0