Invention Grant
- Patent Title: Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
- Patent Title (中): 制备抗体或抗体片段靶向免疫脂质体用于全身给药治疗剂或诊断剂及其用途
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Application No.: US11798296Application Date: 2007-05-11
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Publication No.: US09034330B2Publication Date: 2015-05-19
- Inventor: Esther H. Chang , Kathleen F. Pirollo
- Applicant: Esther H. Chang , Kathleen F. Pirollo
- Applicant Address: US DC Washington
- Assignee: Georgetown University
- Current Assignee: Georgetown University
- Current Assignee Address: US DC Washington
- Agency: Fanelli Haag PLLC
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K9/127 ; C12P21/08 ; A61K39/00 ; A61K9/00 ; A61K41/00 ; A61K47/48 ; A61K49/18 ; G01N33/53
Abstract:
A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex.
Public/Granted literature
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