Invention Grant
- Patent Title: Lipid construct for delivery of insulin to a mammal
- Patent Title (中): 用于向哺乳动物递送胰岛素的脂质构建体
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Application No.: US14511743Application Date: 2014-10-10
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Publication No.: US09034372B2Publication Date: 2015-05-19
- Inventor: John R. Lau , W. Blair Geho
- Applicant: SDG, Inc.
- Applicant Address: US OH Cleveland
- Assignee: SDG, Inc.
- Current Assignee: SDG, Inc.
- Current Assignee Address: US OH Cleveland
- Agency: Saul Ewing LLP
- Agent Kathryn Doyle; Domingos J. Silva
- Main IPC: A61K9/127
- IPC: A61K9/127 ; A61K38/38 ; A61K38/28 ; A61K47/14 ; A61K47/24 ; A61K47/28
Abstract:
The instant invention is drawn to a hepatocyte targeted composition comprising insulin associated with a lipid construct comprising an amphipathic lipid and an extended amphipathic lipid that targets the construct to a receptor displayed by an hepatocyte. The composition can comprise a mixture of free insulin and insulin associated with the complex. The composition can be modified to protect insulin and the complex from degradation. The invention also includes methods for the manufacture of the composition and loading insulin into the composition and recycling various components of the composition. Methods of treating individuals inflicted with diabetes.
Public/Granted literature
- US20150031608A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL Public/Granted day:2015-01-29
Information query
