Invention Grant
US09034624B2 Process for the synthesis of conjugates of glycosaminoglycanes (GAG) with biologically active molecules, polymeric conjugates and relative uses thereof
有权
用于合成糖胺聚糖（GAG）与生物活性分子，聚合物共轭物的缀合物的方法及其相关用途
- Patent Title: Process for the synthesis of conjugates of glycosaminoglycanes (GAG) with biologically active molecules, polymeric conjugates and relative uses thereof
- Patent Title (中): 用于合成糖胺聚糖（GAG）与生物活性分子，聚合物共轭物的缀合物的方法及其相关用途
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Application No.: US13378660Application Date: 2010-06-04
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Publication No.: US09034624B2Publication Date: 2015-05-19
- Inventor: Matteo D'Este , Davide Renier , Gianfranco Pasut , Antonio Rosato
- Applicant: Matteo D'Este , Davide Renier , Gianfranco Pasut , Antonio Rosato
- Applicant Address: IT Abano Terme
- Assignee: FIDIA FARMACEUTICI S.P.A.
- Current Assignee: FIDIA FARMACEUTICI S.P.A.
- Current Assignee Address: IT Abano Terme
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: ITMI2009A1065 20090616
- International Application: PCT/EP2010/003634 WO 20100604
- International Announcement: WO2010/145821 WO 20101223
- Main IPC: C08B37/08
- IPC: C08B37/08 ; A61K31/726 ; C08B37/00
Abstract:
The present invention relates to a process for the synthesis of conjugates of glycosaminoglycanes (GAG) with biologically active molecules of varying nature, comprising small molecules and macro-molecules. In particular, the present invention relates to the conjugation of hyaluronic acid (HA) and its derivatives with polypeptides and proteins with a biological action, such as, for example, interferons, erythropoietins, growth factors, insulin, cytokines, antibodies and hormones.An object of the present invention also relates to isolatable intermediates obtained by the partial or total reaction of GAG with protected amino aldehydes in the conjugation process mentioned above.
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