Invention Grant
US09034859B2 Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
有权
通过羟基甾醇磺酸转移酶的硫酸化氧固醇和氧固醇硫酸化促进脂质体内平衡和肝脏增殖
- Patent Title: Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
- Patent Title (中): 通过羟基甾醇磺酸转移酶的硫酸化氧固醇和氧固醇硫酸化促进脂质体内平衡和肝脏增殖
-
Application No.: US13441241Application Date: 2012-04-06
-
Publication No.: US09034859B2Publication Date: 2015-05-19
- Inventor: Shunlin Ren
- Applicant: Shunlin Ren
- Applicant Address: US VA Richmond
- Assignee: Virginia Commonwealth University
- Current Assignee: Virginia Commonwealth University
- Current Assignee Address: US VA Richmond
- Agency: Whitham Curtis Christofferson & Cook, PC
- Main IPC: A61K31/575
- IPC: A61K31/575 ; A61P3/06 ; A61P1/16 ; C07J31/00 ; A01K67/027 ; C12N9/10 ; A61K48/00
Abstract:
Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25HC3S) to the subject e.g. by 1) administering 25HC3S to the subject; or 2) overexpressing, in the subject, the hydroxysterol sulfotransferase enzyme SULT2B1b, which catalyzes the sulfation of 25-hydroxycholesterol (25HC) to form 25HC3S.
Public/Granted literature
Information query
