Invention Grant
- Patent Title: Acyl piperidine inhibitors of soluble epoxide hydrolase
- Patent Title (中): 可溶性环氧化物水解酶的酰基哌啶抑制剂
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Application No.: US14375224Application Date: 2013-02-01
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Publication No.: US09034903B2Publication Date: 2015-05-19
- Inventor: Bruce D. Hammock , Kin Sing Lee , Christophe Morisseau
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: DLA Piper LLP (US)
- International Application: PCT/US2013/024396 WO 20130201
- International Announcement: WO2013/116690 WO 20130808
- Main IPC: C07D211/58
- IPC: C07D211/58 ; C12N9/14 ; C12Q1/34
Abstract:
Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases. In some embodiments, the present invention provides a method for monitoring the activity of a soluble epoxide hydrolase, the method including contacting the soluble epoxide hydrolase with an amount of a compound of the present invention sufficient to produce a detectable change in the fluorescence of the soluble epoxide hydrolase by interacting with one or more tryptophan residues present in the catalytic site of said sEH.
Public/Granted literature
- US20150011586A1 Acyl Piperidine Inhibitors of Soluble Epoxide Hydrolase Public/Granted day:2015-01-08
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