A “Wearable Electromyography-Based Controller” includes a plurality of Electromyography (EMG) sensors and provides a wired or wireless human-computer interface (HCI) for interacting with computing systems and attached devices via electrical signals generated by specific movement of the user's muscles. Following initial automated self-calibration and positional localization processes, measurement and interpretation of muscle generated electrical signals is accomplished by sampling signals from the EMG sensors of the Wearable Electromyography-Based Controller. In operation, the Wearable Electromyography-Based Controller is donned by the user and placed into a coarsely approximate position on the surface of the user's skin. Automated cues or instructions are then provided to the user for fine-tuning placement of the Wearable Electromyography-Based Controller. Examples of Wearable Electromyography-Based Controllers include articles of manufacture, such as an armband, wristwatch, or article of clothing having a plurality of integrated EMG-based sensor nodes and associated electronics.