The present disclosure provides systems and methods for hardware-enforced protection from malicious software. A device may include at least a security validator module and a security initiator module. A call from a process requesting access to information stored in the device may be redirected to the security initiator module, which may cause the device to change from an unsecured view to a secured view. In the secured view the security validator module may determine whether the call came from malicious software. If the call is determined to be valid, then access to the stored information may be permitted. If the call is determined to be invalid (e.g., from malware), the security software may cause the device to return to the unsecured view without allowing the stored information to be accessed, and may take further measures to identify and/or eliminate process code associated with the process that made the invalid call.