Invention Grant
US09040523B2 Antifungal 5,6-dihydro-4H-pyrrolo[1,2-α][1,4]-benzodiazepines and 6H-pyrrolo[1,2-α][1,4]benzodiazepines substituted with benzene derivatives
有权
用苯衍生物取代的5,6-二氢-4H-吡咯并[1,2-a] [1,4]苯并二氮杂卓和6H-吡咯并[1,2-a] [1,4]苯并二氮杂
![Antifungal 5,6-dihydro-4H-pyrrolo[1,2-α][1,4]-benzodiazepines and 6H-pyrrolo[1,2-α][1,4]benzodiazepines substituted with benzene derivatives](/docs/US/2015-05-26/US09040523B2/abs.jpg.600x600.jpg)
- Patent Title: Antifungal 5,6-dihydro-4H-pyrrolo[1,2-α][1,4]-benzodiazepines and 6H-pyrrolo[1,2-α][1,4]benzodiazepines substituted with benzene derivatives
- Patent Title (中): 用苯衍生物取代的5,6-二氢-4H-吡咯并[1,2-a] [1,4]苯并二氮杂卓和6H-吡咯并[1,2-a] [1,4]苯并二氮杂
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Application No.: US13989233Application Date: 2011-11-18
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Publication No.: US09040523B2Publication Date: 2015-05-26
- Inventor: Lieven Meerpoel , Louis Jules Roger Marie Maes , Kelly de Wit
- Applicant: Lieven Meerpoel , Louis Jules Roger Marie Maes , Kelly de Wit
- Applicant Address: BE Beerse
- Assignee: JANSSEN PHARMACEUTICA NV
- Current Assignee: JANSSEN PHARMACEUTICA NV
- Current Assignee Address: BE Beerse
- Agent Thomas J. Dodd
- Priority: EP10192321 20101124
- International Application: PCT/EP2011/070458 WO 20111118
- International Announcement: WO2012/069380 WO 20120531
- Main IPC: A61K31/5517
- IPC: A61K31/5517 ; C07D487/04
![Antifungal 5,6-dihydro-4H-pyrrolo[1,2-α][1,4]-benzodiazepines and 6H-pyrrolo[1,2-α][1,4]benzodiazepines substituted with benzene derivatives](/abs-image/US/2015/05/26/US09040523B2/abs.jpg.150x150.jpg)
Abstract:
The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines of Formula (I) wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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