Invention Grant
US09040526B2 Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
有权
苄基吡咯烷酮衍生物作为趋化因子受体活性的调节剂
- Patent Title: Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
- Patent Title (中): 苄基吡咯烷酮衍生物作为趋化因子受体活性的调节剂
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Application No.: US13576706Application Date: 2011-02-08
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Publication No.: US09040526B2Publication Date: 2015-05-26
- Inventor: Ian K. Mangion , Percy H. Carter , Jingwu Duan , Andrew J. Tebben
- Applicant: Ian K. Mangion , Percy H. Carter , Jingwu Duan , Andrew J. Tebben
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Elliott Korsen
- International Application: PCT/US2011/024014 WO 20110208
- International Announcement: WO2011/100227 WO 20110818
- Main IPC: A61K31/5365
- IPC: A61K31/5365 ; C07D498/04 ; C07D207/27
Abstract:
The present application describes modulators of MCP-1 or CCR-2 of formula or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, n, W, X, R1 and R6, are defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.
Public/Granted literature
- US20120295899A1 BENZYLPYRROLIDINONE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Public/Granted day:2012-11-22
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