Invention Grant
US09040542B2 Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pryimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea
有权
回旋酶抑制剂（R）-1-乙基-3- [6-氟-5- [2-（1-羟基-1-甲基 - 乙基）哒嗪-5-基] -7-（四氢呋喃-2-基） 吡啶-2-基] -1H-苯并咪唑-2-基]脲
![Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pryimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea](/docs/US/2015-05-26/US09040542B2/abs.jpg.600x600.jpg)
- Patent Title: Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pryimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea
- Patent Title (中): 回旋酶抑制剂（R）-1-乙基-3- [6-氟-5- [2-（1-羟基-1-甲基 - 乙基）哒嗪-5-基] -7-（四氢呋喃-2-基） 吡啶-2-基] -1H-苯并咪唑-2-基]脲
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Application No.: US13908483Application Date: 2013-06-03
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Publication No.: US09040542B2Publication Date: 2015-05-26
- Inventor: Dean Shannon , Brian Luisi , Mariusz Krawiec , Anuj K. Kuldipkumar
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: VERTEX PHARMACEUTICALS INCORPORATED
- Current Assignee: VERTEX PHARMACEUTICALS INCORPORATED
- Current Assignee Address: US MA Boston
- Agency: Brinks Gilson & Lione
- Main IPC: A01N43/54
- IPC: A01N43/54 ; C07D239/42 ; C07D401/04 ; C07D405/14 ; A61K31/4184 ; A61K31/506
![Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pryimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea](/abs-image/US/2015/05/26/US09040542B2/abs.jpg.150x150.jpg)
Abstract:
The present application is directed to solid forms of compounds of formula I: and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infections.
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