Invention Grant
- Patent Title: Method for preparing cyclopropane derivatives
- Patent Title (中): 制备环丙烷衍生物的方法
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Application No.: US14349648Application Date: 2011-11-10
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Publication No.: US09040699B2Publication Date: 2015-05-26
- Inventor: Eleonora Kiss , Erwin Blomsma , Serge De Bruijn , E. J. N. Remy Litjens
- Applicant: Eleonora Kiss , Erwin Blomsma , Serge De Bruijn , E. J. N. Remy Litjens
- Applicant Address: BE Heverlee
- Assignee: Aratana Therapeutics NV
- Current Assignee: Aratana Therapeutics NV
- Current Assignee Address: BE Heverlee
- Agency: Knobbe Martens Olson & Bear LLP
- International Application: PCT/EP2011/069826 WO 20111110
- International Announcement: WO2013/068042 WO 20130516
- Main IPC: C07D313/06
- IPC: C07D313/06 ; C07D239/34 ; C07D239/42 ; C07D473/18 ; C07D473/40
Abstract:
The present invention relates to the preparation of cyclopropane derivatives, in particular 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-4,8-dihydro-1H-purin-6-one, especially via the [(1S,7R)-4-phenyl-3,5-dioxabicyclo[5.1.0]octan-1-yl]methanol intermediate.
Public/Granted literature
- US20150051394A1 METHOD FOR PREPARING CYCLOPROPANE DERIVATIVES Public/Granted day:2015-02-19
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